Arylesterase activity (EC ), one of the three functions of the paraoxonase enzyme (PON1), is thought to protect low-density lipoproteins (LDL) and. ABSTRACT. The arylesterase (ARE) activity linked to the paraoxonase-1 (PON1) gene is known to protect lipoproteins from oxidation and. The aim of this study was to determine whether the para- oxonase (PON1) status, i.e. PON1 activities and phenoty- pes (AA, AB and BB), and its relationship with.


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Our results show that serum paraoxonase and arylesterase activities decrease in preeclampsia, and this situation may be associated with increased LOOH in these patients.

Introduction Preeclampsia is a common disease of human pregnancy and a leading cause of both maternal morbidity and neonatal mortality. Proteinuria and hypertension arylesterase activity or without edema are associated with preeclampsia.

Arylesterase (IPR) < InterPro < EMBL-EBI

Numerous theories on the pathophysiological mechanisms have been investigated; nevertheless, the etiology and pathogenesis of preeclampsia is not yet fully understood [ 1 ]. Endothelial arylesterase activity and inflammation play a role in preeclampsia pathogenesis. Additionally, a reduced invasion of the trophoblast into the uterus and placental hypoxia lead to placental oxidative stress.

If the reactive oxygen species ROS levels exceed the antioxidant capacity or if the antioxidant levels fall in preeclampsia, then generalized oxidative stress will occur. ROS cause oxidation of unsaturated fatty acids and thus increase the levels of lipid peroxidation products.

  • Paraoxonase and Arylesterase Activities in Patients with Preeclampsia
  • Contributing signatures

They confer resistance to organophosphate toxicity [ PMID: Purification and characterization of paraoxon hydrolase from rat liver.

Arylesterase activity precise mechanisms by which the PON1 acts remains unclear, but several in vitro activities have been attributed to this enzyme Nus et al.

Obesity and metabolic syndrome MetS features are main risk factors for the development of atherosclerosis and cardiovascular diseases CVD onset Garg et al. Due to the increasing prevalence of obese people, these accompanying diseases are considered a major concern arylesterase activity public health authorities and many scientific efforts are being carried out to detect, treat and prevent them.

Hypocaloric diets are one of the most common treatments employed to arylesterase activity MetS and related diseases Straznicky et al.


However, more investigation is needed to understand the Arylesterase activity activity role as part of these nutritional strategies. Arylesterase activity the studies carried out are scarce and reported controversial results.

Epigenetics is defined as heritable changes in gene expression that cannot be explained by changes in DNA sequence Christensen et al.

Paraoxonase and Arylesterase Activities in Patients with Preeclampsia

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